CJC-1295 No DAC 5mg

THIS PRODUCT IS INTEDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly in vitro for testing and laboratory experimentation only. All products information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professional. This product is not a drug, food or cosmetic and may not be misbranded, misused or mislabled as a drug food or cosmetic.

CJC-1295 No DAC 5mg

It is a truth universally acknowledged among researchers of endocrine function that CJC-1295 No DAC—or Modified GRF (1-29), as it is known in more precise scientific parlance—stands as one of the most carefully designed synthetic analogs of growth hormone-releasing hormone available to the modern laboratory. This particular peptide, consisting of precisely 29 amino acids arranged in deliberate sequence, represents a refined modification of what was once termed sermorelin, or growth hormone releasing factor (1-29), being the shortest fragment to retain full functional capability.

What distinguishes this peptide from its natural counterpart are four strategic amino acid substitutions, thoughtfully positioned at the 2nd, 8th, 15th, and 27th positions along its chain. These alterations were not undertaken lightly, but rather with considerable deliberation, their purpose being to shield the peptide from the degrading effects of enzymes whilst preserving—indeed, in some respects enhancing—its biological potency. Unlike CJC-1295 with DAC, which possesses a considerably extended duration of action owing to its drug affinity complex, the present peptide maintains what might be termed a more modest half-life of approximately half an hour. This brevity, far from being a disadvantage, renders it particularly well-suited to research protocols where one wishes to observe pulsatile patterns of growth hormone release—those natural rhythms that characterize the healthy functioning of living systems.

The research applications of CJC-1295 No DAC are manifold and of considerable interest to those engaged in endocrine investigation. Scientists employ this peptide to examine the subtle mechanisms by which GHRH receptors respond to stimulation, to trace the pathways through which growth hormone secretion is regulated, and to observe the consequent dynamics of IGF-1 response within controlled experimental conditions. The peptide exhibits remarkable discrimination in its action, binding preferentially to GHRH receptors situated in the anterior pituitary, thereby permitting researchers to study with precision the workings of the somatotropic axis and those intricate patterns that govern endocrine regulation.

CJC-1295 No DAC Structure

Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: 3,367.9 g/mol
CAS Number: 863288-34-0

Amino Acid Sequence:
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

One cannot properly appreciate CJC-1295 No DAC without understanding the elegance of its structural modifications. At position 2, L-alanine has been replaced with its mirror image, D-alanine, a substitution that proves remarkably effective in resisting the action of dipeptidyl peptidase-4, an enzyme that would otherwise hasten the peptide's demise. At position 8, asparagine yields its place to glutamine, thereby reducing the likelihood of amide hydrolysis. The 15th position sees glycine exchanged for alanine—a change that enhances bioactivity—whilst at position 27, leucine supplants methionine, protecting the peptide from oxidative damage. Each of these alterations serves the dual purpose of improving stability and extending the peptide's active duration, though without the pronounced effect achieved by DAC conjugation.

Physical Properties:

• Appearance: A white to off-white lyophilized powder of refined quality and consistent presentation
  
  
• Purity: Not less than 99%
  
  
• Solubility: Demonstrates ready solubility in bacteriostatic water and other sterile aqueous solutions