FOX04-DRI 10mg

THIS PRODUCT IS INTEDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly in vitro for testing and laboratory experimentation only. All products information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professional. This product is not a drug, food or cosmetic and may not be misbranded, misused or mislabled as a drug food or cosmetic.

FOXO4-DRI 10mg     

FOXO4-DRI is a synthetic D-retro-inverso (DRI) peptide engineered to investigate the biology of cellular senescence and healthy aging. Developed from a segment of the Forkhead Box O4 (FOXO4) protein, this modified peptide is designed to disrupt the interaction between FOXO4 and the tumor suppressor protein p53, a mechanism that has made it one of the most extensively studied senolytic compounds in preclinical longevity research.

Cellular senescence is a natural biological process in which damaged or aged cells permanently stop dividing while remaining metabolically active. Over time, these senescent cells accumulate within tissues and release inflammatory signaling molecules collectively known as the senescence-associated secretory phenotype (SASP). Researchers believe this accumulation contributes to tissue dysfunction, chronic inflammation, and numerous age-related biological changes. FOXO4-DRI has emerged as an important research tool because it is designed to selectively target these senescent cells without directly affecting healthy, actively dividing cells in experimental models.

Unlike conventional peptides that primarily regulate endocrine or metabolic pathways, FOXO4-DRI is investigated for its ability to interfere with protein-protein interactions. Specifically, it disrupts the binding between FOXO4 and p53 within senescent cells. This disruption allows p53 to resume its normal cellular function, ultimately triggering programmed cell death (apoptosis) in senescent cells during laboratory studies. This selective mechanism has positioned FOXO4-DRI as a valuable compound in research focused on aging biology, tissue regeneration, and cellular homeostasis.

Since its introduction, FOXO4-DRI has been investigated across numerous preclinical models involving aging, regenerative medicine, musculoskeletal biology, and organ function. Experimental studies have evaluated its effects on kidney biology, skeletal muscle physiology, cartilage health, cardiovascular tissue, pulmonary fibrosis, metabolic function, and chemotherapy-induced tissue damage. Researchers continue to explore how the selective removal of senescent cells influences tissue repair, inflammation, and overall cellular resilience. It remains an investigational research compound with no approved therapeutic use in humans.

Areas of Scientific Research

FOXO4-DRI continues to be investigated in laboratory studies involving:

• Cellular senescence and senolytic biology
• FOXO4-p53 signaling pathways
• Healthy aging and longevity research
• Senescence-associated secretory phenotype (SASP)
• Tissue regeneration and cellular repair
• Stem cell microenvironment research
• Kidney and renal aging
• Skeletal muscle physiology
• Cartilage and connective tissue biology
• Cardiovascular aging research
• Pulmonary fibrosis models
• Neurodegeneration and age-related neurological research
• Inflammatory signaling pathways
• Regenerative medicine

These research areas continue to expand as scientists investigate the biological consequences of selectively eliminating senescent cells and restoring tissue homeostasis.

Product Quality

FOXO4-DRI 10mg is supplied as a lyophilized (freeze-dried) powder, a format commonly used to maximize peptide stability during transportation and long-term laboratory storage. The D-retro-inverso design provides improved resistance to enzymatic degradation compared with conventional peptides, while lyophilization helps preserve molecular integrity until reconstitution for laboratory use.

High-quality research peptides should undergo rigorous analytical testing, including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS), to verify peptide identity, purity, and batch consistency before scientific investigations.

This product is intended exclusively for laboratory and scientific research. It is not intended for human consumption, therapeutic use, or veterinary applications.