PNC-27 5mg

THIS PRODUCT IS INTEDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly in vitro for testing and laboratory experimentation only. All products information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professional. This product is not a drug, food or cosmetic and may not be misbranded, misused or mislabled as a drug food or cosmetic.

PNC-27 5mg                 

PNC-27 is a synthetic 32-amino acid chimeric peptide engineered for experimental oncology research. The peptide combines the HDM-2 (MDM2)-binding domain of the tumor suppressor protein p53 (amino acids 12–26) with a cell-penetrating membrane residency peptide (MRP) derived from the Antennapedia homeodomain. This unique design enables researchers to investigate selective interactions with HDM-2 proteins expressed on the surface of certain cancer cells.

Unlike conventional anticancer compounds that primarily induce apoptosis through intracellular signaling, PNC-27 has demonstrated a distinct mechanism in laboratory studies. Experimental evidence suggests that after binding to membrane-associated HDM-2, PNC-27 forms transmembrane pores, leading to rapid membrane disruption and necrotic cell death in susceptible cancer cells while exhibiting limited activity toward normal cells lacking membrane-bound HDM-2. These findings have been observed primarily in cell culture experiments, and additional preclinical investigation continues to evaluate this mechanism.

One of the primary areas of scientific investigation involves tumor-targeting peptide research. Researchers continue to evaluate PNC-27 across numerous cancer cell models, including studies involving breast, pancreatic, ovarian, colon, leukemia, melanoma, cervical, and other HDM-2-expressing tumor cells. Current research focuses on understanding membrane selectivity, peptide-target interactions, and mechanisms of selective tumor cell destruction. Importantly, no human clinical trials have established safety or efficacy, and PNC-27 remains strictly an investigational laboratory compound.

Scientists are also investigating PNC-27 in studies involving precision oncology, targeted peptide therapeutics, membrane biology, and peptide engineering. Laboratory research seeks to determine how selective membrane targeting may improve understanding of cancer cell biology and contribute to the development of future targeted therapeutic strategies. While preclinical findings have generated scientific interest, current evidence remains limited to in vitro research and early experimental models, requiring substantial additional investigation before any clinical application can be considered.

Areas of Scientific Research

PNC-27 continues to be investigated in laboratory studies involving:

• Experimental oncology
• HDM-2 (MDM2) biology
• p53 signaling research
• Tumor-targeting peptide design
• Cancer cell membrane biology
• Selective membrane pore formation
• Cellular necrosis mechanisms
• Precision oncology research
• Peptide engineering
• Cell-penetrating peptides
• Molecular cancer biology
• Targeted peptide therapeutics
• Membrane protein interactions
• Experimental anticancer peptide development

These research areas continue to improve scientific understanding of peptide-mediated tumor targeting and selective membrane disruption mechanisms. Current evidence remains preclinical, with no approved therapeutic indications or validated human clinical data.

Product Quality

PNC-27 5mg is supplied as a lyophilized (freeze-dried) powder, a formulation commonly used to preserve peptide stability during transportation and long-term laboratory storage. Lyophilization minimizes moisture-related degradation while maintaining peptide integrity until reconstitution according to established laboratory protocols.

High-quality research peptides should undergo analytical verification using recognized laboratory techniques such as High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm peptide identity, purity, and batch consistency. These quality-control procedures support reliable and reproducible scientific investigations.

This product is intended exclusively for laboratory and scientific research. It is not intended for human consumption, therapeutic use, or veterinary applications.